While on treatment tramadol pills, you should always have naloxone drug available at home and work place. Naloxone is very effective in reversing the fatal effects of tramadol overdose. It blocks the effects of opiates and relieves hazardous symptoms caused by increased amounts of opiates in the bloodstream. On seeing the symptoms of overdose of this drug, you should ingest the first dose of naloxone. If the symptoms do not subside after several minutes have passed post the first dose, you should take the second dose of naloxone.